Stocks stall on tepid US economic growth

NEW YORK (AP) ? The stock market stalled Friday after the U.S. economy didn't grow as much as hoped and earnings from a handful of big companies failed to rev up investors.

Economic growth accelerated to a 2.5 percent annual rate in the first three months of the year, the government said. But it was below the 3.1 percent forecast by economists.

The shortfall reinforced the perception that the economy is grinding, rather than charging, ahead. Investors have also been troubled by reports in the last month of weaker hiring, slower manufacturing and a drop in factory orders. Many economists see growth slowing to an annual rate of around 2 percent a year for the rest of the year.

The dollar dropped and U.S. Treasuries, where investors seek safety, rose after the report.

"There are some concerns as we head into the summer," said JJ Kinahan, chief derivatives strategist for TD Ameritrade. "In the last three weeks, we've have seen numbers that weren't exactly what you'd love to see."

Corporate earnings this week have also contained worrisome signs. Many companies missed revenue forecasts from financial analysts, even as they reported higher quarterly profits. For example, Goodyear Tire slipped 3 percent to $12.55 Friday after revenue fell short of analysts' estimates, hurt by lower global tire sales.

Of the companies that have reported earnings so far, 70 percent have exceeded Wall Street's expectations, compared with a 10-year average of 62 percent, according to S&P Capital IQ. However, 43 percent have missed analysts' revenue estimates.

The S&P 500 index was little changed at 1,585, as of 3:35 p.m. having spent most of the day lower.

The Dow was up, gaining 31 points, or 0.1 percent, at 14,717. The index got a big lift from Chevron's stock. Profit for the U.S. oil company beat expectations of financial analysts in the first quarter, pushing shares up $1.29, or 1 percent, to $119.80 on Friday.

Both indexes were up for week and remain slightly below their all-time highs from April 11. The Dow index was 1.2 percent higher this week while the S&P gained 1.9 percent.

The market has been bolstered by the Federal Reserve's easy money policy. And the disappointing growth figure for the economy will ensure that the Fed sticks with its stimulus policy, providing a support for stocks, said Peter Cardillo, chief market economist at Rockwell Global Capital.

"The economic data that we've been getting points to no early exit for the Fed's stimulus," Cardillo said.

The Nasdaq composite was down 4 points at 3,289, a decline of 0.6 percent. The index is still 2 percent higher this week.

The tech-heavy index has lagged both the Dow and the S&P 500 this year, but led the way higher this week, boosted by Microsoft. The software giant, which makes up 5.3 percent of the Nasdaq, is on track to record its biggest weekly gain since January last year, after reporting earnings April 19 that beat Wall Street expectations and revealing an aggressive push into the computer tablet market.

Even Apple, the largest stock in the Nasdaq, had a good week, advancing 5.8 percent to $413.20, despite posting a decline in quarterly profit Tuesday. Apple accounts for 7.6 percent of the index's value and the weekly gain was its biggest since November.

Among big names that investors were focusing on Friday, Amazon.com fell 7 percent to $255.20 after the company warned of a possible loss in the current quarter. And in the first quarter, the online retailer reported lower income fell as it continued to spend heavily on the rights to digital content. Expedia fell 11 percent to $58.15 after the online travel company's reported a quarterly loss.

Homebuilder D.R. Horton surged 8 percent to $26.48 its income nearly tripled thanks to a continuing recovery the housing market. The results were handily beat the forecasts of financial analysts who follow the company.

J.C. Penney jumped 8.5 percent to $16.52 after the billionaire financier George Soros disclosed that he had taken a 7.9 percent stake in the struggling company.

In government bond trading, the yield on the 10-year Treasury note slipped to its lowest rate of the year ? to 1.67 percent from 1.71 percent. The yield has fallen from 2.06 percent six weeks ago.

The dollar weakened 0.2 percent against the euro.

The European currency bought 1.3025 dollars per euro at the end of day, compared with 1.3004 at the start of trading. The dollar index, which measures the strength of the U.S. currency against a group of other world currencies including the Japanese yen and the euro, dropped 0.3 percent, to 82.52 from 82.74.

Source: http://news.yahoo.com/stocks-stall-tepid-us-economic-growth-195845422.html

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95% Gimme The Loot

All Critics (41) | Top Critics (22) | Fresh (39) | Rotten (2)

A thousand-watt jolt of mischief, a spunky, funky, ebullient indie that packs its 81 minutes with cinematic exhilaration.

It may be a slight movie, but it has its sunny charms.

A movie about teenage taggers in the Bronx should be fast and raw, scruffy and loose, and Adam Leon's Gimme the Loot is just that.

As it lopes along, the movie offers a warm but very sharp portrait of New York's have-nots and their uneasy relationship with the haves.

"Gimme the Loot" shouldn't be as appealing and exuberant as it is, it really shouldn't.

Tashiana Washington and Ty Hickson are terrific in the main roles. So is Zo? Lescaze as Ginnie, a spoiled white kid who teaches the taggers a thing or two about drift and being dissolute.

A slim, low-budget coming-of-age tale whose richness lies entirely in its interstices. A keenly observed work that celebrates the unfettered joys of youth, and rewards by reminding of the power of a simple tale told well.

Simultaneously real and hopeful, "Loot" has almost no plot, but when the setting is so fresh and the characters feel so raw and alive, who needs one?

Ghetto laughs with a sophisticated point of view.

...a magical, summery treat.

Promotes robbery and can't be serious in expecting us to care whether Malcolm and Sofia become more than friends.

The winner of the Indie Spirit 'One to Watch' award could never work again and will always have a memorable New York City film to his credit.

An impressive debut feature, Gimme the Loot is also an unusual take on characters who want to leave their stamp on "the city that never sleeps."

Much more grownup than it looks, Gimme the Loot is that rare teen-centric film whose brisk pace is unburdened by sentimentality.

Writer-director Adam Leon has crafted a classic New York story, a film imbued with the fast rhythms and muggy sensations of city life during the summer.

No quotes approved yet for Gimme The Loot. Logged in users can submit quotes.

Source: http://www.rottentomatoes.com/m/gimme_the_loot_2012/

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Astrology Show 5 04/25 by X X Die DrachenhXhle X X | Blog Talk ...

We'll talk to Bobby Seale about the history of The Black Panther Party. Find out what they really meant by terms like "Power To The People" and "Black Power".

Said to be one of the most emotional airings to date, The Hanif J. Williams Show explores the underworld of Human Trafficking with Glendene Grant.

Draft Insider is joined by Co-Host Jason Davis and Peter Bukowski of Sports Illustrated to cover the 2013 NFL Draft live during the entire first round.

Fantasy JAM at the NFL Draft. Join their team along with bloggers from NFL Teams LIVE during the 2013 NFL Draft.

Grab a seat and listen to the Pre-draft discussion and Live Pick By Pick Coverage! Former Jacksonville Jaguar, Tom McManus will joining the show!

The esteemed defense attorney Mr. Joey Jackson will be joining the King Jordan Radio Show on Wednesday April 24th at 11:30AM est.

Once the wedding?s wrapped, why pack your dress in mothballs when it can fetch a pretty penny? says Cheryl Henker of Centsable Way consignment bridal shop.

Today, Michael Zislis is hear to talk about The 8th Annual Ultimate Wine Festival, Sunday, April 28th at the Shade Hotel in Manhattan Beach.

LOTL Welcomes Mr Phil Perry who debuts his new CD " Say Yes ". Phil Perry is a two time winner in the SoulTracks Readers' Choice Awards.

Blue state blues with two savvy conservative ladies, NY Pundit Karen Beseth and Cali's Leslie Eastman.

National Film Critics' Search offers an opportunity to interview celebrities on the Red Carpet in Hollywood! YMCritic Jakiyah and Juanita Richburg Seon give details.

On April 26, 2013, couple Pat Dwyer and Stephen Mosher will have been together for 27 years, the same day their documentary opens in New York City.

Emmy Award winning actress, Tricia Cast talks on her over 25 year role as Nina Webster on the #1 daytime drama, The Young and the Restless.

NWP welcomes Mackenzie Astin, son of Hollywood legends Patty Duke and John Astin. We talk about his new award winning film Hell and Mr. Fudge.

Sidekick Talk Radio shares with you the best information on Martial Arts, and the Martial Arts industry worldwide.

The Well Informed Traveler with Michael McDermott feeding you insider tips through expert guests in the travel, food ,wine and fashion world.

Rick Baker, author of No GoodByes, discussing the disappearance of the McStay family in 2010, when the family mysteriously vanished from their California home.

Newcomer Jack Reynor joins host Robin Milling at The Tribeca Film Festival for his film, What Richard Did, and talks about preparation for Transformers 4.

Award-winning poet Michael Warr visits Talkupy with Annie Lindstrom to celebrate National Poetry Month.

Hasani Pettiford, featured relationship expert for TV-One's reality show Love Addiction, helps single men and women escape "The Friend Zone."

Join vocal communication specialist and singer Michelle Bailly as she teaches us how to express our authentic voice and discover our true identity!

Pop sensation Brittany Smooch has teamed up with Project G.L.A.M. to provide prom dresses and matching accessories for underprivileged girls.

Behind the Mic Radio catches up with Eve Plumb, best known for her portrayal of Jan Brady on The Brady Bunch and talks her new passion; art.

Dennis Daniel talks with voice actor Peter New, best known as Big MacIntosh from the popular series, My Little Pony: Friendship is Magic

One of the greatest guitarists of all time, rock/jazz fusion pioneer, John McLaughlin is going stronger than ever after 4 decades.

Source: http://www.blogtalkradio.com/dragons-lair/2013/04/26/astrology-show-5

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How much money would you be willing to take out in student loans ...

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Source: http://www.wallstreetoasis.com/forums/how-much-money-would-you-be-willing-to-take-out-in-student-loans

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Today in History

Today is Thursday, April 25, the 115th day of 2013. There are 250 days left in the year.

Today's Highlight in History:

On April 25, 1983, 10-year-old Samantha Smith of Manchester, Maine, received a reply from Soviet leader Yuri V. Andropov to a letter she'd written expressing concern about possible nuclear war; Andropov reassured Samantha that the Soviet Union did not want war, and he invited her to visit his country, a trip Samantha made the following July.

On this date:

In 1507, a world map produced by German cartographer Martin Waldseemueller contained the first recorded use of the term "America," in honor of Italian navigator Amerigo Vespucci (vehs-POO'-chee).

In 1792, highwayman Nicolas Jacques Pelletier became the first person under French law to be executed by the guillotine.

In 1859, ground was broken for the Suez Canal.

In 1862, during the Civil War, a Union fleet commanded by Flag Officer David G. Farragut captured the city of New Orleans.

In 1898, the United States formally declared war on Spain.

In 1901, New York Gov. Benjamin Barker Odell Jr. signed an automobile registration bill which imposed a 15 mph speed limit on highways.

In 1915, during World War I, Allied soldiers invaded the Gallipoli (guh-LIHP'-uh-lee) Peninsula in an unsuccessful attempt to take the Ottoman Empire out of the war.

In 1944, the United Negro College Fund was founded.

In 1945, during World War II, U.S. and Soviet forces linked up on the Elbe (EL'-beh) River, a meeting that dramatized the collapse of Nazi Germany's defenses. Delegates from some 50 countries met in San Francisco to organize the United Nations.

In 1959, the St. Lawrence Seaway opened to shipping.

In 1972, Polaroid Corp. introduced its SX-70 folding camera, which ejected self-developing photographs. Actor George Sanders was found dead in his hotel room near Barcelona, Spain; he was 65.

In 1993, hundreds of thousands of gay rights activists and their supporters marched in Washington, D.C., demanding equal rights and freedom from discrimination.

Ten years ago: The Pentagon announced that Army Secretary Thomas White, whose tenure as civilian chief of the military's largest service was marked by tensions with his boss, Defense Secretary Donald Rumsfeld, was leaving office. Georgia lawmakers voted to scrap the Dixie cross from the state's flag.

Five years ago: Three New York police detectives were acquitted in the 50-shot killing of Sean Bell, an unarmed groom-to-be, on his wedding day. Triathlete David Martin, 66, was killed by a great white shark in the waters off San Diego County.

One year ago: The U.S. Supreme Court heard arguments on Arizona's tough immigration law. (A divided court later threw out major parts of the law.) The Senate offered a lifeline to the nearly bankrupt U.S. Postal Service, voting to give the struggling agency an $11 billion cash infusion while delaying controversial decisions on closing post offices and ending Saturday delivery. (The House didn't pass a bill.)

Today's Birthdays: Movie director-writer Paul Mazursky is 83. Actor Al Pacino is 73. Ballroom dance judge Len Goodman (TV: "Dancing with the Stars") is 69. Rock musician Stu Cook (Creedence Clearwater Revival) is 68. Singer Bjorn Ulvaeus (ABBA) is 68. Actress Talia Shire is 67. Actor Jeffrey DeMunn is 66. Rock musician Michael Brown (The Left Banke) is 64. Rock musician Steve Ferrone (Tom Petty & the Heartbreakers) is 63. Country singer-songwriter Rob Crosby is 59. Actor Hank Azaria is 49. Rock singer Andy Bell (Erasure) is 49. Rock musician Eric Avery (Jane's Addiction) is 48. Country musician Rory Feek (Joey + Rory) is 48. TV personality Jane Clayson is 46. Actress Renee Zellweger is 44. Actress Gina Torres is 44. Actor Jason Lee is 43. Actor Jason Wiles is 43. Actress Emily Bergl is 38. Actress Marguerite Moreau is 36. Singer Jacob Underwood is 33. Actress Sara Paxton is 25. Actress Allisyn Ashley Arm is 17.

Thought for Today: "There are two great rules of life, the one general and the other particular. The first is that everyone can, in the end, get what he wants if he only tries. This is the general rule. The particular rule is that every individual is more or less an exception to the general rule." ? Samuel Butler, English author (1835-1902).

(Above Advance for Use Thursday, April 25)

Copyright 2013, The Associated Press. All rights reserved.

Source: http://news.yahoo.com/today-history-050206767.html

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Cancer cells' Achilles' heel revealed

Apr. 24, 2013 ? Scientists from the Manchester Collaborative Centre for Inflammation Research (MCCIR) have discovered why a particular cancer drug is so effective at killing cells. Their findings could be used to aid the design of future cancer treatments.

Professor Daniel Davis and his team used high quality video imaging to investigate why the drug rituximab is so effective at killing cancerous B cells. It is widely used in the treatment of B cell malignancies, such as lymphoma and leukemia -- as well as in autoimmune diseases like rheumatoid arthritis.

Using high-powered laser-based microscopes, researchers made videos of the process by which rituximab binds to a diseased cell and then attracts white blood cells known as natural killer (NK) cells to attack. They discovered that rituximab tended to stick to one side of the cancer cell, forming a cap and drawing a number of proteins over to that side. It effectively created a front and back to the cell -- with a cluster of protein molecules massed on one side.

But what surprised the scientists most was how this changed the effectiveness of natural killer cells in destroying these diseased cells. When the NK cell latched onto the rituximab cap on the B cell, it had an 80% success rate at killing the cell. In contrast, when the B cell lacked this cluster of proteins on one side, it was killed only 40% of the time.

Professor Davis says: "These results were really unexpected. It was only possible for us to unravel the mystery of why this drug was so effective, through the use of video microscopy. By watching what happened within the cells we could clearly identify just why rituximab is such an effective drug -- because it tended to reorganise the cancerous cell and make it especially prone to being killed."

He continues: "What our findings demonstrate is that this ability to polarise a cell by moving proteins within it should be taken into consideration when new antibodies are being tested as potential treatments for cancer cells. It appears that they can be up to twice as effective if they bind to a cell and reorganise it."

The findings from this study have been published online today on the website of the journal Blood. The research was carried out in collaboration with MedImmune, the global biologics research and development arm of AstraZeneca.

Commenting on the research Dr Matt Sleeman, Senior Director of Biology at MedImmune said: "Not only is this a great observation that can influence how we as a biotech company identify and design future therapies, it also shows the innovative 'out of the box' thinking that can be achieved by working in close partnership with academics at the top of their field. This unique partnership, bringing together industry and academia, demonstrates a real catalyst of scientific change within the UK, and I am excited by the potential of the MCCIR to bring further innovation that could ultimately bring benefit to patients."

Much of the research for this study was carried out during Professor Davis' time at Imperial College London. He will be continuing to use high quality video imaging at a microscopic level to investigate immunology at the MCCIR.

Professor Davis and MedImmune would like to acknowledge the funding they received from the Medical Research Council which helped make this study possible.

Videos: http://bloodjournal.hematologylibrary.org/content/early/2013/04/23/blood-2013-02-482570/suppl/DC1

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Story Source:

The above story is reprinted from materials provided by Manchester University.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.

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Journal Reference:

1. D. Rudnicka, A. Oszmiana, D. K. Finch, I. Strickland, D. J. Schofield, D. C. Lowe, M. A. Sleeman, D. M. Davis. Rituximab causes a polarisation of B cells which augments its therapeutic function in NK cell-mediated antibody-dependent cellular cytotoxicity. Blood, 2013; DOI: 10.1182/blood-2013-02-482570

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/most_popular/~3/uNtotQMZrJk/130424102940.htm

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'Smoking gun' from North Korea's Feb. nuclear test found

By Fredrik Dahl

VIENNA (Reuters) - Radioactive gases that could have come from North Korea's nuclear test in February have unexpectedly been detected, a global monitoring body said on Tuesday, possibly providing the first "smoking gun" evidence of the explosion.

But the April 9 measurement - almost two months after Pyongyang said it had carried out the underground detonation - gave no indication of whether plutonium or highly enriched uranium was used, it said.

The time that had passed before the so-called noble gases were picked up made it "very difficult" to distinguish between the two fissile materials, said spokeswoman Annika Thunborg of the Comprehensive Nuclear-Test-Ban Treaty Organisation (CTBTO).

The isolated east Asian state is believed to have tested plutonium bombs in its previous two such blasts, in 2006 and 2009. Any switch to uranium would increase international alarm as it could enable Pyongyang to greatly expand its arsenal.

North Korea threatened nuclear attacks on the United States, South Korea and Japan after new U.N. sanctions were imposed in response to its latest atomic test. But U.S. officials have cast serious doubt on whether it could launch a nuclear missile.

Pyongyang's third nuclear test was registered virtually instantaneously via seismic signals around the world. But no radioactive traces that would have constituted conclusive proof were found in the immediate weeks afterwards.

The Vienna-based CTBTO, which has a worldwide network of monitoring stations, said in mid-March that it was highly unlikely any such radioactivity would be detected.

But Tuesday's statement said it made a significant detection of radioactive noble gases two weeks ago in Takasaki, Japan, about 1,000 km (620 miles) from the test site. Lower levels were picked up at another station in Ussuriysk, Russia.

"Two radioactive isotopes of the noble gas xenon were identified, xenon-131m and xenon-133, which provide reliable information on the nuclear nature of the source," it said.

"Detection of radioactive noble gas more than seven weeks after an event is indeed unusual. We did not expect this and it did not happen in 2009," the CTBTO added, referring to the reclusive country's previous nuclear test.

BOTH BOMB PATHS

Large amounts of xenon gases are produced in fission, a nuclear reaction occurring both in nuclear arms and reactors.

"We are confident that the (North Korean) test site is among the possible source regions," the CTBTO said. But it could still not "exclude completely" that the radioactive traces came from somewhere else.

North Korea's February test yielded a stronger blast than its previous explosion four years ago, and Pyongyang said it had made progress in miniaturizing an atomic weapon, essential to fitting it into the cone of a missile.

Tension on the Korean peninsula soared after the test.

While estimates of the explosive power of the latest test vary, most officials and experts assessed it was at least five kilotons - still smaller than the power of the atomic bomb the United States dropped on Hiroshima in World War Two.

North Korea abandoned plutonium production six years ago in response to international pressure, but later acknowledged that it had built facilities to produce enriched uranium, which can also be used in bombs if refined to a high degree.

Experts say plutonium, a byproduct of nuclear reactors, can be difficult to use as bomb material because specifications have to be precise. It could be easy for North Korea to make large quantities of highly enriched uranium.

"It would not surprise me if they have been pursuing both paths to the bomb," Siegfried Hecker, a prominent U.S. scientist who has often visited North Korea, said in an interview published this month on a Stanford University website.

The test-ban treaty was negotiated in the 1990s but has not taken effect because some holders of nuclear technology have not yet ratified it, including the United States and China.

But the CTBTO already monitors possible breaches, deploying about 290 stations around the world to look out for signs of atomic tests, including seismic waves and radioactive traces.

(Editing by Mark Heinrich)

Source: http://news.yahoo.com/gases-consistent-north-koreas-february-test-found-nuclear-092211467.html

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